The California Department of Public Health (CDPH) has noted a recent increase in mpox cases in California and across the nation, and encourages physicians to consider mpox in their differential diagnoses of people with any diffuse or localized rash.   

CDPH recently issued a health alert urging providers to test persons with suspected mpox and offer the vaccine to populations at increased risk of severe mpox disease. While the mpox vaccine is effective at preventing illness and reducing disease severity, infections after vaccination are possible and testing is warranted among vaccinated persons who have compatible signs and symptoms.

Vaccination of persons in high-risk groups is especially important with upcoming holiday gatherings, but the vaccine is available to anyone who requests it.

For more information, see the CDPH health advisory.